What is the cannabinoid receptor-2 (CB2).
- Similar to CB1, CB2 is a G protein receptor that serves as a target for endocannabinoids and phytocannabinoids.
- These CB2 receptors are primarily immunomodulatory and anti-inflammatory.
- They are expressed on the cell membranes of B cells, T cells and macrophages.
- When signaled, CB2 receptors are generally inhibitory to immune cell activation.
- Expression of CB2 receptors is inducible and the number of receptors is increased by inflammation.
- As found in studies conducted in mice, reduced CB2 receptor signaling results in increased severity of inflammation in multiple organs.
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